Venice, 1468. Sosia Simeon, a free-spirited sensualist, is the lover of many men in the fabled city, though married to one she despises. On the edge of the Grand Canal, Wendelin von Speyer sets up the first printing press in Venice and looks for the book that will make his fortune. When he tempts fate by publishing Catullus, the poet whose desperate and unrequited love inspired the most tender and erotic poems of antiquity, a scandal is set in motion that will change all their lives forever.